Berberine is a novel mitochondrial calcium uniporter (MCU) inhibitor that disrupts MCU-EMRE assembly
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Junwei Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Hai-Zhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, , Xin Pan
This study identifies Berberine as a mitochondrial calcium uniporter inhibitor that disrupts MCU-EMRE assembly and reduces mitochondrial calcium overload in mice.
Advanced Science · Feb 7, 2025Peer-reviewedCell Biology