A dose-dependent switch in translation capacity controls the transcription factor response to H2O2 stress
Chance Parkinson, Woody March-Steinman, Elizabeth Jose, Lisa Shanks, Andrew L. Paek
The paper shows that high H2O2 stress inhibits translation to prevent TF accumulation, while low H2O2 allows TFs like p53 and NRF2 to drive stress responses.
bioRxiv · Jan 31, 2026 · PreprintMolecular Biology