Andrew L. Paek

A dose-dependent switch in translation capacity controls the transcription factor response to H2O2 stress

The paper shows that high H2O2 stress inhibits translation to prevent TF accumulation, while low H2O2 allows TFs like p53 and NRF2 to drive stress responses.

Quiescence Induction Triggers Acute Accumulation of DNA Double-Strand Breaks That Drive Quiescence Heterogeneity

The paper shows that inducing quiescence in human RPE cells causes rapid DSB accumulation, leading to quiescence heterogeneity and requiring DSB repair for cell cycle re-entry.

Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors.

This study uses high-throughput screens in human cells with authentic SARS-CoV-2 virus to identify neutralizing monoclonal antibodies and kinase inhibitors with minimal host toxicity.

Spatio-temporal feature based deep neural network for cell lineage analysis in microscopy images

The paper introduces a spatio-temporal deep neural network for cell lineage analysis in microscopy images, achieving high performance on multiple datasets.