The Neosartorya (Aspergillus) fischeri antifungal protein NFAP2 has low potential to trigger resistance development in Candida albicans in vitro
Gábor Bende, Nóra Zsindely, Krisztián Laczi, Zsolt Kristóffy, Csaba Papp, Attila Farkas, Liliána Tóth, Szabolcs Sáringer, László Bodai, Gábor Rákhely, Florentine Marx, László Galgóczy
This study shows that C. albicans develops resistance to NFAP2 with fewer genetic changes and less phenotypic impact than to fluconazole, suggesting NFAP2 is a promising antifungal with low resistance potential.
Microbiology Spectrum · Nov 19, 2024Peer-reviewedMicrobiology