A Proposed Statistical Approach for Conducting Longitudinal Assessment of Circulating Tumor DNA
Christopher R. Pretz, Jiemin Liao, Caroline M. Weipert, Leslie A. Bucheit, Leylah M. Drusbosky, Amar K. Das
This paper proposes a statistical framework using hierarchical mixed-effects models to analyze ctDNA dynamics in liquid biopsy data, finding that a hierarchical linear spline model best captures patient-level ctDNA evolution.
bioRxiv · Apr 3, 2025 · PreprintGenomics