GenomicsbioRxivPreprint
A Proposed Statistical Approach for Conducting Longitudinal Assessment of Circulating Tumor DNA
Christopher R. Pretz, Jiemin Liao, Caroline M. Weipert…·Amar K. Das
This paper proposes a statistical framework using hierarchical mixed-effects models to analyze ctDNA dynamics in liquid biopsy data, finding that a hierarchical linear spline model best captures patient-level ctDNA evolution.
DOI 10.1101/2025.04.03.646973