Author

Sadegh Marzban

Moffitt Cancer CenterORCID 0000-0002-9435-017XUnclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cell type annotation· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Jeffrey WestiD· 4 shared Alexander R.A. AndersoniD· 2 shared Antonio L. AmelioiD· 1 shared Ari Barnett· 1 shared Bijal Dinesh ShahiD· 1 shared Chandler Gantenbee· 1 shared Christine H. ChungiD· 1 shared Curtis A. GravenmieriD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersCancer Biology

Jeffrey WestORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

140 Years of mathematical modeling in oncology through AI-assisted curation

Franco Pradelli, Maximilian A.R. Strobl, Sadegh Marzban, François de Kermenguy, Ari Barnett, Katyayni Ganesan, David A. Hormuth, Sara Hamis, Dhananjay Bhaskar, Guillermo Lorenzo, Alexander R.A. Anderson, Jeffrey West

This paper curates a large corpus of mathematical oncology literature using AI, revealing its evolution from cancer biology to therapeutic modeling over 140 years.

bioRxiv · Jun 17, 2026 · PreprintCancer Biology

Mechanistic learning to predict and understand minimal residual disease

Sadegh Marzban, Mark Robertson‐Tessi, Jeffrey West

This paper develops a mechanistic learning framework to predict BCR::ABL1 fusion gene status and minimal residual disease using clinical data, finding that stem-like cell state is a strong predictor.

bioRxiv · May 6, 2026 · PreprintCancer Biology

Collagen remodeling promotes a GPCR-mediated mechanosensory immune checkpoint in ADGRG1+ CD8+ T cells and serves as a spatial biomarker of response to immunotherapy

Sonal Srivastava, John Joseph Powers, Jay H. Mehta, Sadegh Marzban, Ryunosuke Nozaki, Laxmi Swetha Karanam, Jacob Torrez, Harish S. Bharambe, Farhoud Faraji, Ritu Chaudhary, Pino Bordignon, Jacqueline Giliberti, Robbert J.C. Slebos, Joseph Johnson, Chandler Gantenbee, , Antonio L. Amelio

The paper identifies collagen remodeling as a mechanism that activates a GPCR-mediated immune checkpoint in ADGRG1+ CD8+ T cells, influencing response to immunotherapy.

bioRxiv · Dec 22, 2025 · PreprintCancer Biology

Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia

Curtis A. Gravenmier, Sadegh Marzban, Yi-Han Tang, Nancy Gillis, Bijal Dinesh Shah, Lynn C. Moscinski, Ling Zhang, Jeffrey West

This paper develops a mathematical model of cell state transitions in B-ALL to correlate with BCR::ABL1 status, MRD, and relapse risk using flow cytometry data.

Cancer Research Communications · Nov 26, 2025Peer-reviewedCancer Biology

A hybrid PDE-ABM model for viral dynamics with application to SARS-CoV-2 and influenza

Sadegh Marzban, Renji Han, Nóra Juhász, Gergely Röst

The paper introduces a hybrid PDE-ABM model to simulate viral dynamics in cell populations, showing it can predict SARS-CoV-2 and influenza infections and replicate experimental results.

Royal Society Open Science · Nov 1, 2021Peer-reviewedSystems Biology