Collagen remodeling promotes a GPCR-mediated mechanosensory immune checkpoint in ADGRG1+ CD8+ T cells and serves as a spatial biomarker of response to immunotherapy
Sonal Srivastava, John Joseph Powers, Jay H. Mehta, Sadegh Marzban, Ryunosuke Nozaki, Laxmi Swetha Karanam, Jacob Torrez, Harish S. Bharambe, Farhoud Faraji, Ritu Chaudhary, Pino Bordignon, Jacqueline Giliberti, Robbert J.C. Slebos, Joseph Johnson, Chandler Gantenbee, , Antonio L. Amelio
The paper identifies collagen remodeling as a mechanism that activates a GPCR-mediated immune checkpoint in ADGRG1+ CD8+ T cells, influencing response to immunotherapy.
bioRxiv · Dec 22, 2025 · PreprintCancer Biology