Joseph Johnson

Spatially resolved multimodal hallmarks of response to neoadjuvant immunotherapies in the melanoma ecosystem in 2D and 3D

The paper analyzes the spatial molecular architecture of melanoma tumors under different immunotherapy regimens and identifies biomarkers predicting response to treatment.

BCL11B targeting in tumor CD8+ T cells amplifies anti-tumor response by blocking exhaustion while promoting stemness and cytotoxicity

This paper shows that reducing BCL11B in CD8+ T cells enhances anti-tumor response by preventing exhaustion and boosting stemness and cytotoxicity.

Collagen remodeling promotes a GPCR-mediated mechanosensory immune checkpoint in ADGRG1+ CD8+ T cells and serves as a spatial biomarker of response to immunotherapy

The paper identifies collagen remodeling as a mechanism that activates a GPCR-mediated immune checkpoint in ADGRG1+ CD8+ T cells, influencing response to immunotherapy.

Eco-evolutionary Guided Pathomic Analysis to Predict DCIS Upstaging

This study uses ecological analysis of hypoxia and acidosis biomarkers to improve prediction of DCIS upstaging by identifying habitat-based metabolic phenotypes and spatial niches.

Mathematical modeling of clonal interference by density-dependent selection in heterogeneous cancer cell lines

The paper models clonal interference in cancer cell lines using phenotypic data to predict growth rate and carrying capacity differences between karyotypes.