Inhibition of IL-6 signaling with tocilizumab improves stroke outcomes in aged mice but requires sex-specific dosing
Jacob Hudobenko, Eunyoung Angela Lee, Gabriela Delevati Colpo, Louise Atadja, Grant W. Goodman, Shuning Huang, Lucy Couture, Anjali Chauhan, Louise D. McCullough
This study shows that tocilizumab improves stroke recovery in aged male mice but requires higher doses for females due to sex-specific differences in sIL-6R levels.
bioRxiv · May 6, 2026 · PreprintNeuroscience