Louise D. McCullough

This study shows that tocilizumab improves stroke recovery in aged male mice but requires higher doses for females due to sex-specific differences in sIL-6R levels.

This study examines chronic neurological changes after ischemic stroke in mice and humans, finding persistent inflammation, neuronal damage, and signs of accelerated aging in the brain.

This study identifies vascular luminal glycocalyx loss and complement activation as key drivers of BBB injury in hyperglycemic stroke, showing that targeting complement after reperfusion improves outcomes.

This study identifies sex-specific metabolites in MCI patients through untargeted serum metabolomic profiling, revealing lipid pathway differences and potential biomarkers for AD.