Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis
Lynn Radamaker, Julian Baur, Stefanie Huhn, Christian Haupt, Ute Hegenbart, Stefan Olaf Schönland, Akanksha Bansal, Matthias Schmidt, Marcus Fändrich
The paper presents cryo-EM structures of a patient-derived amyloid fibril from systemic AL amyloidosis, revealing structural breaks and a 180-degree rotation around a disulfide bond.
Nature Communications · Feb 8, 2021Peer-reviewedMolecular Biology