Dual Ligand Cooperation at the Plasma Membrane Drives Transport of Engineered Small Extracellular Vesicles Across Brain Endothelial Cells
Inês Albino, Elena Ambrosetti, Margarida Vaz, Ana I. Teixeira, Paula Sampaio, Miguel M. Lino, Lino Ferreira
This study engineers small extracellular vesicles with dual ligand targeting to enhance their uptake and transport across brain endothelial cells, showing improved delivery to the brain choroid plexus.
Journal of Controlled Release · May 15, 2026Peer-reviewedBioengineering