Lino Ferreira

A room-temperature ⁸⁹Zr⁴⁺ radiolabelling strategy for small extracellular vesicles with enhanced plasma stability for PET Imaging

This paper introduces a radiolabeling strategy for small extracellular vesicles using ⁸⁹Zr⁴⁺, achieving stable plasma labeling for PET imaging without altering vesicle properties.

Dual Ligand Cooperation at the Plasma Membrane Drives Transport of Engineered Small Extracellular Vesicles Across Brain Endothelial Cells

This study engineers small extracellular vesicles with dual ligand targeting to enhance their uptake and transport across brain endothelial cells, showing improved delivery to the brain choroid plexus.

Vascularized midbrain assembloids show neuroinflammation and dopaminergic neuron vulnerability in Parkinsons Disease

This study creates vascularized midbrain organoids to model Parkinson's disease, showing increased neuroinflammation and dopaminergic neuron vulnerability in patient-derived assembloids.

Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux

This study shows that soft extracellular matrix reduces autophagic flux and disrupts redox balance in neuronal cells, mimicking neurodegenerative disease features.