Paula Sampaio

This study engineers small extracellular vesicles with dual ligand targeting to enhance their uptake and transport across brain endothelial cells, showing improved delivery to the brain choroid plexus.

This study shows that embryonic AUUUC repeat RNA in zebrafish causes axonal and synaptic defects leading to adult motor dysfunction.

The paper shows that premalignant cells increase tensile forces at cell-cell and cell-matrix adhesions before losing them, promoting proliferation and malignant transformation.

The paper shows that an ATTTC repeat insertion in an Alu element enhances a DAB1 enhancer, leading to neuronal dysfunction in SCA37.

This study shows a small-molecule agonist of KIF2C enhances DNA repair and mitigates aging phenotypes in progeria and Down syndrome models.