BioinformaticsbioRxivPreprint
Exploring the Druggable Conformational Space of Protein Kinases Using AI-Generated Structures
Noah B. Herrington, David F. Stein, Yan Chak Li…·Avner Schlessinger
This study evaluates AI-generated kinase structures to explore underrepresented conformational states, showing that reducing MSA depth in AlphaFold2 can predict novel conformations for 398 kinases.
11 citations