Yan Chak Li

KinAce integrates kinase-substrate interactions from multiple databases to enable visual exploration in systems contexts.

This study evaluates AI-generated kinase structures to explore underrepresented conformational states, showing that reducing MSA depth in AlphaFold2 can predict novel conformations for 398 kinases.

The paper introduces Ensemble Integration (EI), a late integration method for multimodal biomedical data, achieving more accurate predictions than individual modalities and early integration approaches.