eTRex Reveals Oncogenic Transcriptional Regulatory Programs Across Human Cancers
Zeyu Lu, Yuqiu Yang, Qiang Zheng, Feng Gao, Lori Xu, Xinlei Wang
The paper develops eTRex, a variational Bayesian model, to analyze 4,819 ATAC-seq datasets and create a pan-cancer atlas of transcriptional regulator profiles, revealing common and context-specific regulators.
bioRxiv · Jan 20, 2026 · PreprintBioinformatics