Deficits in mitochondrial function and glucose metabolism seen in sporadic and familial Alzheimers disease derived Astrocytes are ameliorated by increasing hexokinase 1 expression.
Simon Bell, Hollie E. Wareing, Alexander Hamshaw, Suman De, Elizabeth J. New, Pamela J. Shaw, Matteo De Marco, Annalena Venneri, Daniel J. Blackburn, Laura Ferraiuolo, Heather Mortiboys
This study shows that AD astrocytes have reduced mitochondrial and glycolytic function, which can be improved by increasing hexokinase 1 expression.
bioRxiv · Mar 23, 2023 · PreprintNeuroscience