Author
University of SheffieldORCID 0000-0003-0785-4116Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Agnieszka N. Urbanek, Alexander J. Dear, David Rhodes…·Suman De
This study identifies two distinct amyloid-β intermediates that drive Alzheimer's pathology and shows their suppression reduces plaque burden and improves cognition in mice.
Agnieszka N. Urbanek, Emma F. Garland, Emily E. Prescott…·Suman De
This study investigates how variations in protein aggregate size, composition, and mutations affect biological functions in Alzheimer's and Parkinson's diseases.
Zengjie Xia, Emily E. Prescott, Agnieszka N. Urbanek…·Suman De
The paper shows that apoE isoforms modulate Aβ aggregation, clearance, and toxicity in Alzheimer's disease, with implications for therapeutic strategies.
Simon Bell, Hollie E. Wareing, Alexander Hamshaw…·Heather Mortiboys
This study shows that AD astrocytes have reduced mitochondrial and glycolytic function, which can be improved by increasing hexokinase 1 expression.