Sarah A. Middleton

Single-cell multi-ancestry regulatory map of systemic lupus erythematosus

The paper constructs a multi-ancestry single-cell eQTL map for SLE, identifying colocalized eQTLs with GWAS loci and highlighting cell-type-specific regulatory mechanisms.

Comprehensive catalog of dendritically localized mRNA isoforms from sub-cellular sequencing of single mouse neurons

The paper identifies dendritically localized mRNA isoforms in mouse neurons using sub-cellular RNA sequencing and provides a resource of known localized RNAs.

PIVOT: Platform for Interactive Analysis and Visualization of Transcriptomics Data

PIVOT provides an R-based application with a graphical interface to simplify transcriptomics data analysis for non-programmers by integrating multiple tools and enabling interactive exploration.

Complete fold annotation of the human proteome using a novel structural feature space

The paper introduces a machine learning method for accurate protein fold recognition, achieving over 96% accuracy and predicting folds for 34,330 human protein domains.