Fly wounds and tumors restrict macrophages via a matrix degradation-moderating protease inhibitor
Kavya Adiga, Yoshiki Sakai, Matin Nawabi, Sofia Mendez-Lopez, Tsai‐Ching Hsi, David H. Bilder
This study shows that Tep3 limits macrophage attachment to damaged and transformed epithelia by inhibiting MMP1 proteolytic activity, reducing BM DAMP production and promoting tumor progression.
bioRxiv · Aug 12, 2025 · PreprintGenetics