Multi-ancestry GWAS deciphers genetic architecture of abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Tanmoy Roychowdhury, Derek M. Klarin, Michael G. Levin, Joshua Michael Spin, Yae Hyun Rhee, Alicia C. Deng, Colwyn Ansel Headley, Ida L. Surakka, Noah L. Tsao, Corry Gellatly, Verena Zuber, Fred Y. Shen, Whitney Hornsby, Ina Holst Laursen, Shefali S. Verma, , Scott M. Damrauer
This study identifies 144 genetic loci associated with abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target through Mendelian Randomization and pre-clinical validation.
medRxiv · May 27, 2022 · PreprintGenetic & Genomic Medicine