Jonas Ghouse

Plasma proteomics enhances genetic risk prediction and biological understanding of venous thromboembolism

This study integrates plasma proteomics with genetic risk scores to improve VTE prediction and identify potential therapeutic targets.

GWAS of amiodarone-induced thyroid dysfunction: Applications for genotype-guided risk stratification

This paper identifies genetic variants associated with amiodarone-induced thyroid dysfunction and shows they improve risk prediction beyond general thyroid disease PRS.

Genome-wide association analysis reveals insights into the molecular aetiology underlying dilated cardiomyopathy

This study identifies 80 genetic loci and 61 effector genes associated with dilated cardiomyopathy through GWAS and integrates transcriptomic data to uncover biological pathways and cellular states involved in the disease.

Genomics of chronic cough unravels neurological pathways

This study identifies seven novel genetic loci associated with chronic dry cough and ACEi-induced cough, implicating neurological genes and highlighting potential therapeutic targets.

Biallelic variants in POPDC2 cause a novel autosomal recessive syndrome presenting with cardiac conduction defects and variable hypertrophic cardiomyopathy

Common variants near the bradykinin receptor B2 gene are associated with angioedema induced by angiotensin-converting-enzyme inhibitor treatment - a genome wide association study

This GWAS identifies common variants near BDKRB2 associated with angioedema from ACEi treatment, showing genetic risk and blood pressure effects.