Beyond consensus sequence: a quantitative scheme for inferring transmission using deep sequencing in a bacterial transmission model
Madikay Senghore, Hannah M. Read, Priyali Oza, Sarah Johnson, Hemanoel Passarelli‐Araujo, Bradford P. Taylor, Stephen Ashley, Alex Grey, Alanna Callendrello, Robyn S. Lee, Matthew R. Goddard, Thomas Lumley, William Paul Hanage, Siouxsie Wiles
The paper develops a model to infer bacterial transmission using deep sequencing data from a mouse model, showing that within-host variant abundance differences can accurately identify transmission pairs.
bioRxiv · Oct 17, 2022 · PreprintGenomics