Genetic & Genomic MedicineBriefings in BioinformaticsPeer-reviewed
A novel two-sample Mendelian randomization framework integrating common and rare variants: application to assess the effect of HDL-C on preeclampsia risk
Yu Zhang, Ming Li, David M. Haas…·Qi Yan
This paper introduces MR-CARV, a two-sample Mendelian randomization framework integrating common and rare variants to assess the causal effect of HDL-C on preeclampsia risk, showing improved statistical power and precision.