A novel two-sample Mendelian randomization framework integrating common and rare variants: application to assess the effect of HDL-C on preeclampsia risk
Yu Zhang, Ming Li, David M. Haas, C Noel Bairey Merz, Tsegaselassie Workalemahu, Kelli K. Ryckman, Janet M. Catov, Lisa D Levine, Alexa A. Freedman, George R. Saade, Jiaqi Hu, Hongyu Zhao, Xihao Li, Nianjun Liu, Qi Yan
This paper introduces MR-CARV, a two-sample Mendelian randomization framework integrating common and rare variants to assess the causal effect of HDL-C on preeclampsia risk, showing improved statistical power and precision.
Briefings in Bioinformatics · Jan 1, 2026Peer-reviewedGenetic & Genomic Medicine