Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response selectively induced by protein misfolding
Michela Ciccarelli, Anna E. Masser, Jayasankar Mohanakrishnan Kaimal, Jordi Planells, Claes Andréasson
The paper genetically inactivates HSF1 in yeast to show it uniquely senses protein misfolding and triggers a specific transcriptional stress response, distinct from heat shock.
bioRxiv · May 5, 2023 · PreprintMolecular Biology