Daniel Backenroth

SHaploseek: A sequencing-only high-resolution implementation of comprehensive preimplantation genetic testing

SHaploseek is a sequencing-only method for comprehensive preimplantation genetic testing that achieves high concordance with existing methods and improves sensitivity in subtelomeric regions.

Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century

The paper analyzes genome-wide data from medieval German Jews to show the Ashkenazi founder event occurred before the 14th century, with genetic heterogeneity not present in modern Ashkenazi Jews.

Utility of polygenic embryo screening for disease depends on the selection strategy

This paper predicts the utility of polygenic embryo screening for disease based on selection strategies and finds that selecting the lowest PRS embryo can significantly reduce disease risk.

A test for Hardy-Weinberg equilibrium on the X chromosome for sex-biased admixed populations

The paper develops statistical tests to detect deviations from Hardy-Weinberg equilibrium on the X chromosome in sex-biased admixed populations, showing improved performance over existing methods.

FUN-LDA: A latent Dirichlet allocation model for predicting tissue-specific functional effects of noncoding variation

FUN-LDA predicts tissue-specific functional effects of noncoding variants by integrating epigenetic data, showing higher accuracy than existing methods in eQTL and GWAS analyses.