Author

Angela M. Christiano

Columbia University Irving Medical CenterORCID 0000-0002-6071-9784Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:eQTL / molecular QTL mapping· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alin VonicaiD· 1 shared Amir KargeriD· 1 shared Andre Henri GoyiD· 1 shared Angelica M. Castano· 1 shared Anne O’Donnell‐LuriaiD· 1 shared Arunjot SinghiD· 1 shared Benjamin TyckoiD· 1 shared Bruce B. RileyiD· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSystems Biology

Alin VonicaORCID

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3 papers

Recent·Most cited

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs

Catherine Do, Emmanuel LP Dumont, Martha C. Salas, Angelica M. Castano, Huthayfa Mujahed, Leonel Maldonado, Arunjot Singh, Sonia C. DaSilva‐Arnold, Govind Bhagat, Soren Lehman, Angela M. Christiano, Subha Madhavan, Péter L. Nagy, Peter H.R. Green, Rena Feinman, , Benjamin Tycko

The paper maps allele-specific DNA methylation in normal and cancer tissues, identifying disease-associated regulatory SNPs that are missed by other methods.

Genome biology · Jun 28, 2020Peer-reviewedGenomics

Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin

Alin Vonica, Neha Bhat, Keith D. Phan, Jinbai Guo, Lăcrimioara Iancu, Jessica A. Weber, Amir Karger, John Wesley Cain, Etienne C. E. Wang, Gina M. DeStefano, Anne O’Donnell‐Luria, Angela M. Christiano, Bruce B. Riley, Samantha J. Butler, Victor A Luria

This study identifies Apcdd1 as a dual inhibitor of BMP and Wnt signaling pathways in multiple organisms, revealing its role in development and disease.

Developmental Biology · Apr 19, 2020Peer-reviewedSystems Biology

FUN-LDA: A latent Dirichlet allocation model for predicting tissue-specific functional effects of noncoding variation

Daniel Backenroth, Zihuai He, Krzysztof Kiryluk, Valentina Boeva, Lynn Pethukova, Ekta Khurana, Angela M. Christiano, Joseph D. Buxbaum, Iuliana Ionita‐Laza

FUN-LDA predicts tissue-specific functional effects of noncoding variants by integrating epigenetic data, showing higher accuracy than existing methods in eQTL and GWAS analyses.

bioRxiv · Aug 2, 2017 · PreprintBioinformatics