The cytoplasmic scaffolding protein PCNA as a new regulator of activation of the classical NRLP3 inflammasome
Chloé Lopes, Karen Aymonnier, Nicolas Cagnard, Géraldine Falgarone, Léa Tourneur
This study identifies PCNA as a cytoplasmic regulator of NLRP3 inflammasome activation by interacting with NEK7 and modulating inflammasome-mediated cytokine secretion and pyroptosis.
bioRxiv · Jul 8, 2025 · PreprintImmunology