Keiichi Homma

Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletions that are mostly in intrinsically disordered regions of the encoded proteins

The paper analyzes indels in internal exons and finds they are mostly nonframeshifting, short, and encode intrinsically disordered regions, with tandem repeats contributing significantly to indel frequency in long exons.

Exon Elongation Added Intrinsically Disordered Regions to the Encoded Proteins and Facilitated the Emergence of the Last Eukaryotic Common Ancestor

The paper proposes a model for the evolution of eukaryotic proteins from prokaryotic ones, linking exon elongation to the emergence of intrinsically disordered regions and multiple structural domains.