Hiroto Anbo

The paper identifies neuronal stop-codon readthrough in Drosophila, showing it produces C-terminal extensions that alter protein localization.

The paper analyzes indels in internal exons and finds they are mostly nonframeshifting, short, and encode intrinsically disordered regions, with tandem repeats contributing significantly to indel frequency in long exons.

The paper proposes a model for the evolution of eukaryotic proteins from prokaryotic ones, linking exon elongation to the emergence of intrinsically disordered regions and multiple structural domains.