Tertiary and quaternary structure remodeling by occupancy of the substrate binding pocket in a large glutamate dehydrogenase
Melisa Lázaro, Nicolás Chamorro, Jorge Pedro López-Alonso, Diego Charro, Rodolfo Maximiliano Rasia, Gonzalo Jiménez‐Osés, Mikel Valle, María‐Natalia Lisa
This study uses cryo-EM to show that substrate and cofactor binding in mycobacterial L-GDH180 induces tertiary and quaternary structural remodeling.
Protein Science · Mar 25, 2026Peer-reviewedMolecular Biology