Gonzalo Jiménez‐Osés

This paper engineers conformational switches using nanobodies that fold upon ligand binding, enabling customizable receptors and sensors for biomarkers and drugs.

This study uses cryo-EM to show that substrate and cofactor binding in mycobacterial L-GDH180 induces tertiary and quaternary structural remodeling.

This paper synthesizes and characterizes UVI3502, a novel CB1 receptor antagonist/inverse agonist, showing high affinity for CB1 and low affinity for CB2, with potential interactions with GPR55.