Tsvi Tlusty

Geometric-Chemical Distance Between Protein Surfaces

The paper introduces IFACE, a method to compute geometric-chemical distances between protein surfaces and provides surface maps, showing improved performance over existing methods in classification and clustering.

Linking Tissue Morphology and Tissue Healing in a Cell-Fate Model

This study links tissue morphology and healing capacity using a cell-fate model, showing that only tissues with large contiguous domains can heal from injuries.

Statistical Survey of Chemical and Geometric Patterns on Protein Surfaces as a Blueprint for Protein-mimicking Nanoparticles

This paper surveys chemical and geometric patterns on protein surfaces and compares them to nanoparticle ligand patterns, finding similarities and differences that inform synthetic nanoparticle design.

A comprehensive survey of developmental programs reveals a dearth of tree-like lineage graphs and ubiquitous regeneration

The paper uses a generative model to analyze developmental programs and finds that cell-type lineage graphs are rarely tree-like and often involve regeneration through pluripotent cells.

Unspecific binding but specific disruption of the group I intron by the StpA chaperone

The paper investigates how the RNA chaperone StpA interacts with group I introns, revealing a mechanism involving specific disruption and non-specific binding governed by charge patterns.

Physical model of the sequence-to-function map of proteins

The paper introduces a physical model of protein evolution that links DNA sequences to functional proteins through mechanical modes and shows how mutations correlate with amino acid interactions in functional modes.