The Src-family kinase Lyn plays a critical role in establishing and maintaining B cell anergy by suppressing PI3K-dependent signaling
Brigita E. Fiske, Scott M. Wemlinger, Bergren W. Crute, Andrew Getahun
This study shows Lyn is essential for B cell anergy by suppressing PI3K signaling in autoreactive B cells, highlighting its role in preventing autoimmunity.
Nature Communications · Mar 8, 2026Peer-reviewedImmunology