The protective effect of NGF mutant CHF6467 in SH SY5Y cells exposed to Aβ(1-42): a pharmacometabolomic approach
Enza Napolitano, Carmen Marino, Manuela Grimaldi, Michela Buonocore, Angelo Santoro, Gaetano Barbato, Anna Maria D’Ursi
This study uses NMR-metabolomics to show CHF6467 mitigates Aβ(1-42)-induced metabolic changes in SH-SY5Y cells by promoting phospholipid precursors, reducing glutamate excitotoxicity, and restoring energy metabolism.
bioRxiv · Oct 6, 2026 · PreprintCell Biology