An Immunocompetent Mouse Model of Degarelix Induced Chemical Castration to Investigate Acquired Resistance to Androgen Deprivation.
Amanda Robotham, Diane L. Costanzo-Garvey, Grace M. Waldron, Leah M. Cook, Grinu Mathew
This study uses an immunocompetent mouse model to show that Degarelix-induced chemical castration suppresses prostate cancer tumor growth initially but leads to acquired resistance over time.
bioRxiv · Oct 9, 2026 · PreprintCancer Biology