Author

Leah M. Cook

National Institutes of HealthORCID 0000-0002-9996-7419Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Amanda RobothamiD· 2 shared Diane L. Costanzo-GarveyiD· 2 shared Grinu MathewiD· 2 shared Adrian R. BlackiD· 1 shared Angie RizzinoiD· 1 shared Benjamin A. TeplyiD· 1 shared Borum RyuiD· 1 shared Catherine S. JohnsoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Amanda RobothamORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

An Immunocompetent Mouse Model of Degarelix Induced Chemical Castration to Investigate Acquired Resistance to Androgen Deprivation.

Amanda Robotham, Diane L. Costanzo-Garvey, Grace M. Waldron, Leah M. Cook, Grinu Mathew

This study uses an immunocompetent mouse model to show that Degarelix-induced chemical castration suppresses prostate cancer tumor growth initially but leads to acquired resistance over time.

bioRxiv · Oct 9, 2026 · PreprintCancer Biology

An Integrated Preclinical Platform for Lethal Neuroendocrine Prostate Cancer from Rapid Autopsy Bone and Liver Metastases.

Borum Ryu, Thomas C. Caffrey, Sriya Sridhar, Catherine S. Johnson, Ramia J. Salloom, Kabhilan Mohan, Grace Waldron, Amanda Robotham, Ethan M Wilcox, Diane L. Costanzo-Garvey, Janice Taylor, James Talaska, Rachel Rhatigan, Quan P. Ly, Heather C. Jensen-Smith, , Grinu Mathew

This paper establishes patient-derived models of neuroendocrine prostate cancer (NEPC) from metastases, showing they retain tumor heterogeneity and can model metastatic progression.

bioRxiv · Jul 23, 2026 · PreprintCancer Biology