Author

Hans‐Michael Tautenhahn

Jena University HospitalORCID 0000-0002-9722-9391Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Organism:human· 1

Frequent Co-Authors

Jan GrzegorzewskiiD· 2 shared Matthias KönigiD· 2 shared Beatrice Stemmer MalloliD· 1 shared Jonas KüttneriD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 5 mutual co-author links

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2 shared papersSystems Biology

Jan GrzegorzewskiORCID

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2 papers

Recent·Most cited

Insights into Intestinal P-glycoprotein Function using Talinolol: A PBPK Modeling Approach

Beatrice Stemmer Mallol, Jan Grzegorzewski, Hans‐Michael Tautenhahn, Matthias König

This paper develops a PBPK model of talinolol to study P-gp function and its impact on pharmacokinetics under various conditions.

bioRxiv · Nov 21, 2023 · PreprintSystems Biology

A physiologically based pharmacokinetic model for CYP2E1 phenotyping via chlorzoxazone

Jonas Küttner, Jan Grzegorzewski, Hans‐Michael Tautenhahn, Matthias König

This study develops a PBPK model to assess CYP2E1 activity using chlorzoxazone, showing how ethanol consumption, abstinence, and liver impairment affect its metabolism.

bioRxiv · Apr 12, 2023 · PreprintSystems Biology