Systems BiologybioRxivPreprint
A physiologically based pharmacokinetic model for CYP2E1 phenotyping via chlorzoxazone
Jonas Küttner, Jan Grzegorzewski, Hans‐Michael Tautenhahn, Matthias König
This study develops a PBPK model to assess CYP2E1 activity using chlorzoxazone, showing how ethanol consumption, abstinence, and liver impairment affect its metabolism.
3 citations