Li‐Ru Zhao

Transcriptomic analysis reveals new reparative mechanisms of SCF and GCSF - reduced neuropathology in aged APPPS1 mice

This study identifies molecular mechanisms by which SCF+G-CSF reduces AD pathology in aged APP/PS1 mice through transcriptomic analysis of differentially expressed genes and pathway modulation.

Hematopoietic growth factors Regulate Entry of Monocytes into the Adult Brain via Chemokine Receptor CCR5

This study shows that SCF and G-CSF enhance monocyte adhesion to brain endothelial cells via CCR5, facilitating their entry into the adult brain to replenish perivascular macrophages.

Single cell RNA sequencing reveals immunomodulatory effects of stem cell factor and granulocyte colony-stimulating factor treatment in the brains of aged APP/PS1 mice

This study uses single-cell RNA sequencing to show SCF+G-CSF treatment modulates microglia and myeloid cells in aged APP/PS1 mice, enhancing immune responses and Aβ clearance.

Stem cell factor and granulocyte colony-stimulating factor promote remyelination in the chronic phase of severe traumatic brain injury

This study shows that SCF+G-CSF treatment enhances remyelination in the chronic phase of severe TBI by promoting oligodendrocyte progenitor cell proliferation.