Full-length tRNAs lacking a functional CCA tail are selectively sorted into the lumen of extracellular vesicles
Chantal Scheepbouwer, Ernesto Aparicio‐Puerta, Cristina Gómez‐Martín, Monique A.J. van Eijndhoven, Esther E.E. Drees, Leontien Bosch, Daphne de Jong, Thomas D. Wurdinger, Josée M. Zijlstra, Michael Hackenberg, Alan Gerber, Dirk Michiel Pegtel
The paper identifies that full-length tRNAs with truncated CCA tails are selectively sorted into extracellular vesicles, suggesting a new mechanism for EV cargo selection.
bioRxiv · May 12, 2024 · PreprintMolecular Biology