Alan Gerber

The paper uses CRISPRi screening to identify Pol III gene dependencies in cancer cells, finding glioblastoma models are resilient to Pol III gene repression.

This study shows that EGFR inhibition in glioblastoma does not lead to broad kinome rewiring but instead results in increased EGFR abundance and partial restoration of EGFR signaling.

The paper defines the minimal sequence requirements of RNA polymerase II CTD across transcriptional stages using structural analysis and synthetic constructs, revealing a 'zipper' model for PIC assembly and transcription progression.

The paper identifies that full-length tRNAs with truncated CCA tails are selectively sorted into extracellular vesicles, suggesting a new mechanism for EV cargo selection.

The paper shows that RNA Polymerase II directly regulates tRNA gene expression by interfering with RNA Polymerase III function, specifically during serum starvation.