Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin
Cheng Xu, Wei‐Bin Shen, E. Albert Reece, Hidetoshi Hasuwa, Christopher R. Harman, Sunjay Kaushal, Peixin Yang
This study shows maternal diabetes causes premature senescence in the neuroepithelium, leading to neural tube defects, which can be prevented by senomorphic rapamycin.
Science Advances · Jun 30, 2021Peer-reviewedDevelopmental Biology