Impaired Spatiotemporal Encoding of Social Behavior and Anxiety in the Prefrontal Cortex of Mice Lacking ASD-Risk Gene Shank3.
Hailee Walker, Damhyeon Kwak, Prakash Devaraju, Bethany C. Curd, Amaya M. Chikuni, Nicholas Alonzo Frost
This study shows that loss of Shank3 in mice affects the recruitment of heterogeneous neuronal populations in the prefrontal cortex during social and anxiety-related behaviors.
bioRxiv · Jul 15, 2025 · PreprintNeuroscience