Nicholas Alonzo Frost

Impaired Spatiotemporal Encoding of Social Behavior and Anxiety in the Prefrontal Cortex of Mice Lacking ASD-Risk Gene Shank3.

This study shows that loss of Shank3 in mice affects the recruitment of heterogeneous neuronal populations in the prefrontal cortex during social and anxiety-related behaviors.

Context-invariant socioemotional encoding by prefrontal ensembles

This study investigates how prefrontal neurons encode socioemotional information across different environments, finding that context and socioemotional representations overlap but remain orthogonal.

Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice.

This study identifies persistent excitatory neuron dysfunction in Chd8 haploinsufficient mice through single nucleus transcriptomics and behavioral analysis.

Co-release of opposing signaling molecules controls the escalation and release of aggression

The paper identifies that co-released opposing signaling molecules, Neurokinin B and GABA, from Tac2+ neurons in the mPFC control distinct phases of aggression escalation and release in mice.

Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction

The paper identifies heterogeneous neuronal populations in the medial prefrontal cortex activated during social interaction using immediate early gene expression analysis.

Dynamic patterns of correlated activity in the prefrontal cortex encode information about social behavior

The paper shows that correlated neural activity in the prefrontal cortex encodes social behavior information, and this synergy is disrupted in Shank3-deficient mice.