Author

Claudia C. Pastrana

Washington University in St. LouisORCID 0000-0002-9748-2020Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Amy M. Bertino· 1 shared Angelique Gilbert· 1 shared Kimmo PorkkaiD· 1 shared Matthew J. WalteriD· 1 shared Samuli EldforsiD· 1 shared Sridhar Nonavinkere SrivatsaniD· 1 shared Sumit RaiiD· 1 shared Tareq HossaniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Amy M. Bertino

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1 paper

Recent·Most cited

Sensitivity to ATR-CHK1 pathway inhibition in AML/MDS is enhanced by SRSF2 mutations and reduced by RUNX1 loss

Samuli Eldfors, Sumit Rai, Vineet Sharma, Tareq Hossan, Claudia C. Pastrana, Amy M. Bertino, Angelique Gilbert, Sridhar Nonavinkere Srivatsan, Kimmo Porkka, Matthew J. Walter, Timothy Aaron Graubert

This study identifies SRSF2 and U2AF1 mutations as biomarkers of sensitivity to ATR-CHK1 pathway inhibitors and RUNX1 mutations as a mechanism of resistance in MDS/AML.

Leukemia · Oct 6, 2026Peer-reviewedCancer Biology