Author

Aaron Hakim

Broad InstituteORCID 0000-0002-9752-8826Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Arvo Justice· 1 shared Brenda R. Flam· 1 shared Chandra Sekhar Uma Shankar· 1 shared Edward B. O’Neill· 1 shared Enzo Cabrera· 1 shared Hiromi SesakiiD· 1 shared Jerry Cruz Rodriguez· 1 shared Kawtar Al Khalloufi· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

Arvo Justice

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1 paper

Recent·Most cited

OPA1 controls mitochondrial dysfunction-driven liver fibrosis in MASLD

Xinting Yu, Pinzhu Huang, Arvo Justice, Aaron Hakim, Yoshiko Nanki, Zaur Abilov, Edward B. O’Neill, Jerry Cruz Rodriguez, Enzo Cabrera, Marla Sagatelian, Chandra Sekhar Uma Shankar, Brenda R. Flam, Kawtar Al Khalloufi, Hiromi Sesaki, 荣世松, Yury V. Popov

The paper identifies OPA1 as a key regulator of liver fibrosis in MASLD by linking mitochondrial dysfunction to fibrotic responses through mito-DAMP release and hepatic stellate cell activation.

bioRxiv · Sep 27, 2026 · PreprintGenetics